Pigtown is a neighborhood in the southwest area of Baltimore, bordered by Martin Luther King Jr. Boulevard to the east, Monroe Street to the west, Russell Street to the south, and West Pratt Street to the north. The neighborhood acquired its name during the second half of the 19th century, when the area was the site of butcher shops and meat packiā¦Pigtown is a neighborhood in the southwest area of Baltimore, bordered by Martin Luther King Jr. Boulevard to the east, Monroe Street to the west, Russell Street to the south, and West Pratt Street to the north. The neighborhood acquired its name during the second half of the 19th century, when the area was the site of butcher shops and meat packing plants to process pigs transported from the Midwest on the B&O Railroad; they were herded across Ostend and Cross Streets to be slaughtered and processed.