Chiefs quarterback Patrick Mahomes had his worst game of the season in Buffalo on Sunday and he did something that he's never done before in the NFL.

It's Josh Allen vs. Patrick Mahomes, once again, on Sunday afternoon. The Buffalo Bills are hosting the Kansas City Chiefs in a premier matchup at Highmark Stadium in Orchard Park, New York on Sunday.

The NFL announced its decision on a potential punishment on a play involving Kansas City Chiefs quarterback Patrick Mahomes.

Two of this generation's premier quarterbacks square off again with Allen looking to improve on his 4-1 regular-season mark vs. Mahomes.

The Bills have tried to follow the Eagles blueprint to beating Mahomes by beefing up their front four. They signed Joey Bosa in free agency this offseason, extended edge rusher Gregory Rousseau and used their first five draft picks on defense, including three along the defensive line ( T.J. Sanders, Landon Jackson, Deone Walker ).

The Kansas City Chiefs gain 24 yards against the Buffalo Bills on a reception from quarterback Patrick Mahomes to wide receiver Rashee Rice.

The San Francisco 49ers go on the road and get the win over the New York Giants, 34-24. Mac Jones ended the game 19 of 24 (14 of 14 first half) for 235 yards passing and two touchdowns. Christian McCaffrey rushed for 106 yards and a touchdown, along with 67 receiving yards and a touchdown reception.