Reserch sheds light on how mutated PSEN2 accelerates familial Alzheimer's disease progression
Alzheimer's disease is a debilitating condition that slowly robs people of their memory and cognitive abilities, affecting millions of people worldwide.
techexplorist1d
Uncovering the genetic basis of rare mutations in Alzheimer’s disease
Alzheimer’s disease is a progressive condition that impairs memory and cognitive function, affecting millions globally.
EurekAlert!1d
The genetic roots of rare mutations in Alzheimer’s disease
Alzheimer’s disease is a debilitating condition that slowly robs people of their memory and cognitive abilities, affecting millions of people worldwide. Familial Alzheimer’s disease (FAD), a rare ...
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Study reveals that almost all individuals with two copies of the APOE4 gene develop signs of Alzheimer's
It is known that mutations in three genes, APP, PSEN1, and PSEN2, are involved in the development of autosomal dominant early-onset Alzheimer's disease—which is clearly considered genetic and ...
inceptivemind21h
The genetic basis of rare mutations in Alzheimer’s disease
Familial Alzheimer's disease (FAD), a rare inherited form of the condition, is associated with mutations in several genes, ...
Nature9d
Membrane trafficking articles from across Nature Portfolio
This latest research reveals that changes in PSEN2 expression accelerate amyloid build-up, disrupt lysosomal function, and weaken synaptic connections. These findings spotlight PSEN2 as a powerful ...