A team of researchers from Academia Sinica and National Taiwan University has identified the Drosophila Cul2 substrate adaptor DmZer1 as a key regulator of protein quality control, acting at the ...

Autophagy is the cellular equivalent of a housekeeping system. When operating correctly, it eliminates damaged proteins, ...

Zellweger Spectrum Disorder (ZSD) is a term for a rare group of neurodegenerative disorders that are caused by mutations in various genes. These mutations interfere with peroxisome levels. Peroxisomes ...

Like all living things, cellular structures break down over time and must be recycled. In cells, this process is called autophagy. Most neurodegenerative diseases are related to the improper ...

Autophagy—meaning "self-eating" in Greek—is a fundamental cellular mechanism that preserves cell health by recycling and degrading worn-out or dysfunctional components. Serving as an essential ...

Autophagy, the cell’s essential 'housekeeping' process, involves degrading and recycling damaged organelles, proteins, and other components to prevent clutter. This vital mechanism, found in all life ...

New study reveals how the ketone body β-hydroxybutyrate can halt toxic protein buildup, paving the way for innovative therapies against Alzheimer's and aging-related brain dysfunction. Study: ...

Dr. Kang’s research focuses on the molecular pathways underlying aberrant proteinopathy and neurotoxicity in Alzheimer’s disease (AD) and Related Dementias (ADRDs), including Frontotemporal dementia ...

Altered dopaminergic neurotransmission underlies a variety of neurological and neuropsychiatric diseases, including playing a central role in the neurodegenerative processes that lead to Parkinson’s ...

Autophagy—meaning “self-eating” in Greek—is a fundamental cellular mechanism that preserves cell health by recycling and degrading worn-out or dysfunctional components. Serving as an essential ...