For the first time, researchers have observed the ion pumps that activate cell transport and signal systems. This ensures the function of biomolecular mechanisms. Each calcium pump measures only a few ...

The pumping action of the calcium pump protein—an intricate molecular machine with several moving parts that helps control muscle contraction—has been detailed with exquisite precision by RIKEN ...

Like entrance and exit doors on a building, a cell's outer surface has doors -- channels, pumps, and transporters that selectively control what molecules enter or exit. In the immune system, T cells ...

New research from Aarhus University with international collaborations has revealed that natural aSN activates an important calcium pump in the cell membrane. The protein alpha-synuclein (aSN) has long ...

Scientists have long thought that calcium transport into mitochondria is a key signal linking cardiac workload, or how hard the heart pumps, with energy production. Now, in a major breakthrough, ...

Dendritic spines compartmentalize calcium, and this could be their main function. We review experimental work on spine calcium dynamics. Calcium influx into spines is mediated by calcium channels and ...

This study identifies a non-canonical role of p22 phox (a subunit of NADPH oxidases) in cardiac protection: by directly binding the sarcoplasmic reticulum calcium pump SERCA2a and preventing its ...

Research published ahead of print in the journal Function suggests the plasma membrane Ca2+ ATPase (PMCA) pump helps regulate cytosolic calcium signaling. Cytosolic calcium is found within the cells' ...

UK scientists have identified a new way to kill pancreatic cancer cells by 'pulling the plug' on the energy generator that fuels calcium pumps on their cell surface. The study, published in the ...