Excessive fibroblast proliferation and metabolic reprogramming are hallmarks of pathological cardiac remodeling, contributing significantly to impaired cardiac function. This study investigates the ...

Scripps Research postdoctoral researcher Kaushik Chanda explores the mechanisms by which non-coding transcripts modulate neuronal function and structural integrity during learning and memory loss.

Circular RNA (circRNA) is a unique type of non-coding RNA produced by back splicing of mRNA to form the covalent junction without 3’-5’ polarity and poly(A) tail. CircRNA was first discovered about 30 ...

Despite the scientific relevance of circular RNAs (circRNAs), the study of these RNAs in non-model organisms, especially in sheep, is still in its infancy. On the other hand, while some studies have ...

It's no secret that we need new ways to treat and detect disease, including cancer. Specifically, we need better biomarkers that can be used for diagnosis and better ways to selectively get medicine ...

A new review article highlights the transformative role of circular RNA (circRNA) in cancer, revealing its potential as both a key player in tumor biology and a promising avenue for future therapies.

On the left are three forms of the same RNA molecule, which is stabilised into a single form (on the right) by mitoxantrone. Ribonucleic acids (RNAs) serve as messengers between DNA and protein ...

Although the genetic material of most living organisms is DNA, various self-replicating agents rely instead on RNA, including RNA viruses and viroids, which are infectious RNA molecules that are ...

The Mass General Brigham Gene and Cell Therapy Institute (GCTI) today announced it has launched the RNA Therapeutics Core, a first-of-its-kind, state-of-the-art facility and resource to advance the ...

Ribonucleic acid, commonly known as RNA, is involved in many biological functions, and some, including gene silencing, are utilized to cure diseases. RNA has recently gained attention as a promising ...

The use of RNA is a promising approach for a growing range of therapeutics and vaccines, but overcoming a few challenges would enable it even further. Stability and persistence in the body are ...