Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, No. 21 (Nov., 1990), pp. 8192-8196 (5 pages) Group I introns are characterized by a set of conserved sequence ...

Group II intron RNAs self-splice in vitro but only at high salt and/or Mg²⁺ concentrations and have been thought to require proteins to stabilize their active structure for efficient splicing in vivo.

Proper expression of proteins in eukaryotic cells requires precise stitching of protein-coding fragments, or exons, from precursor mRNAs that also contain non-coding introns. This process, known as ...

BACKGROUND: Alternative splicing plays crucial roles in normal heart development and cardiac disease by influencing protein-coding sequences, functional domains, and molecular networks. However, a ...

Pre-mRNA splicing in a subset of human short introns is governed by a distinct mechanism involving a new splicing factor Protein-coding genes carry the blueprint for protein production. In higher ...

Alison Tang (UC Santa Cruz) describes her lab’s studies on full-length transcript characterization of the mutated SF3B1 transcriptome in chronic lymphocytic leukemia Sponsored content brought to you ...

Our cells have to generate a massive number of proteins, and there is a carefully orchestrated procedure for doing so. It starts when active genes are transcribed into RNA, and while that RNA ...

When you can’t take down the kingpin, go after his accomplices. This strategy may work for cancer as well, according to scientists at Fred Hutch Cancer Center and Memorial Sloan Kettering Cancer ...

The interrupted non-coding regions in pre-mRNAs, termed “introns,” are excised by “splicing” to generate mature coding mRNAs that are translated into proteins. As human pre-mRNA introns vary in length ...

Pre-mRNA splicing in a subset of human short introns is governed by a distinct mechanism involving a new splicing factor, new research finds. The interrupted non-coding regions in pre-mRNAs, termed ...