Medically reviewed by Robert Burakoff, MD Key Takeaways Most of your liver is on the right side of your body, under your rib cage and above your stomach, with part of it extending into the middle and ...

Using human liver samples and a mouse model of cirrhosis, researchers identified epigenetic overactivation of the inflammatory PAF–PAF-R pathway in hepatic macrophages as a key driver of liver damage.

Cells use their molecular architecture to regulate their metabolic functions, and repairing diseased cells' architecture to a healthier state can also repair metabolism, according to a study led by ...

Though an essential gateway to the liver, NTCP had not been well described until now. Na+-taurocholate co-transporting polypeptide (NTCP) is a protein located exclusively in the membrane of liver ...

Three-dimensional (3D) geometrical models are potent tools for quantifying complex tissue features and exploring structure–function relationships. However, these models are generally incomplete due to ...

Over the past decade, advances in organoid culturing methods have enabled the growth of three-dimensional cellular cultures in vitro with increasing fidelity with respect to the cellular composition, ...

Liver transplantation often depends on decisions made under pressure. In deceased donation, teams must quickly judge whether ...

The liver produces bile, which the intestine uses for digestion. For the transport of bile, the liver relies on a network of microscopic tubings, known as bile canaliculi, formed by liver cells called ...

This research reveals for the first time that selective upregulation of ROCK2 in liver endothelial cells and perivascular hepatic stellate cells serves as a core mechanism driving the progression of ...

Researchers from Miguel Hernández University of Elche (UMH) in Spain have identified an effective strategy to reduce structural liver damage and improve hepatic vascular function in cirrhosis. The ...

Scientists have published a ground-breaking study of the structure and function of a central protein in the liver: NTCP, a cellular-entry pathway for bile salts, but also for certain hepatitis viruses ...