For decades, KRAS, one of the deadliest cancer-causing mutant proteins, has been considered impossible to target due to its ...

Mutations in a protein called KRAS fuel some of the most lethal cancers. Designing drugs to disable KRAS has proved ...

Today, doctors are increasingly looking at the genetic makeup of each patient’s tumor to guide treatment decisions.

A research team led by Purdue University’s W. Andy Tao has discovered of a new type of protein modification related to ...

Discover how TP53 mutations in adult leukaemia impact treatment outcomes and potential strategies for improved patient care.

Zongertinib provided substantial clinical benefit for patients with advanced or metastatic HER2-mutant advanced non-small cell lung cancer, surpassing the historical standard of care efficacy for this ...

Some of your most important life partners are the mitochondria that power all your cells. You and these little cellular ...

The study investigated r ezatapopt (PC14586), a first-in-class small molecule designed to selectively bind and reactivate the ...

A Nature study identifies a previously unknown protein modification, O-2-hydroxyglutarylation, driven by the oncometabolite ...