EurekAlert!

Increase of PCSK9 expression in diabetes promotes VEGFR2 ubiquitination to inhibit endothelial function and skin wound healing

The upregulation of PCSK9 expression in endothelial cells of diabetic patients induces ubiquitination of VEGFR2 and inhibits the VEGFR2/ AKT/eNOS -ERK signaling pathway by promoting the interaction of ...
EurekAlert!

PCSK9 is a co-activator of platelet function beyond its role in cholesterol homeostasis

Barcelona, Spain - 27 Aug 2017: PCSK9 is a co-activator of platelet function beyond its role in cholesterol homeostasis, according to research presented at ESC Congress today.1 The findings suggest ...
Medscape

PCSK9 Inhibition Likely Doesn't Promote Heart Failure: Genetic Study

A new case-control genetic study is reassuring in finding no association between a genetic proxy for pharmacologic PCSK9 inhibition and either heart failure or adverse cardiac remodeling in a large ...
Kaleido Scope

PCSK9 loss-of-function variants and risk of infection and sepsis in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort

Elevated proprotein convertase subtilisin/kexin type 9 (PCSK9) levels have been associated with adverse outcomes in patients hospitalized for sepsis. PCSK9 loss-of-function (LOF) variants area ...
Nature

PCSK9 antibodies: a dividend of the genomics revolution

PCSK9 antibodies effectively lower the LDL-cholesterol level and, therefore, address an unmet clinical need in patients with either refractory hypercholesterolaemia, statin intolerance, or an elevated ...
Nature

Insights into a PCSK9 structural groove: a harbinger of new drugs to reduce LDL-cholesterol

PCSK9 enhances LDL cholesterol (LDL-c) levels by escorting the liver LDL receptor (LDLR) to endosomes and lysosomes for degradation. PCSK9 monoclonal antibodies and RNA-antisense formulations are ...
MedPage Today

It’s Complicated: PCSK9 variants, LDL-C Levels, and CV and All-cause Mortality

Many randomized trials have established that the risk reduction for cardiovascular (CV) disease is proportional to the absolute reduction of low-density-lipoprotein cholesterol (LDL-C). Nevertheless, ...
News Medical

Scientists cast new light on function of long-mysterious PCSK9 mutation

High levels of low-density lipoproteins, parcels of lipids and protein that carry cholesterol, are a leading risk factor for heart disease. Many cholesterol medications lower LDL, some of them by ...
Science Daily

Group of enzymes could have a positive impact on health, from cholesterol to osteoporosis

Recent studies on a group of PCSK enzymes could have a positive impact on health, from cholesterol to osteoporosis. Recent studies conducted at the Institut de recherches cliniques de Montréal (IRCM) ...
Science Daily

Study sheds light on the function of a long-mysterious PCSK9 mutation

High LDL a leading risk factor for heart disease. Many cholesterol medications lower LDL, some of them by targeting the protein PCSK9. Scientists now report on an investigation into why experiments on ...
sciencex

PCSK9 protein's function and impact on cardiovascular disease

How does PCSK9 function and what is the impact of this protein on cardiovascular disease? A research team coordinated by Dr. Nabil G. Seidah, researcher at the IRCM and at Université de Montréal, has ...