A possible new treatment for impaired brain blood flow and related dementias is on the horizon. Research by scientists at the ...

Medically important phospholipids are observed in cellular condensates. [Top] PIP 2 (green), a phospholipid involved in cell signaling, is observed in nuclear speckle condensates (red). [Bottom] PIP 3 ...

Because of the large number of phospholipids, their highly active metabolism and our lack of understanding of protein-lipid specificity, lipid signaling is a particularly challenging subject to study.

The signaling phosphatidylinositol lipids PI(4,5)P₂ (PIP₂) and PI (3,4,5)P₃ (PIP₃) bind nuclear receptor 5A family (NR5As), but their regulatory mechanisms remain unknown. Here, the crystal structures ...

Replacing a missing brain lipid may calm overactive blood vessels and restore healthy blood flow—opening a new path toward treating dementia.

Phospholipases PLA1, PLA2, PLC, and PLD hydrolyze phospholipids to produce corresponding lysophospholipids and fatty acids. Red arrows indicate the corresponding hydrolysis sites. B) Phospholipases ...

THE role of lipids as predictors of coronary heart disease has become of considerable interest during the past two decades. Many individual lipids, such as the serum cholesterol, phospholipid and ...

The Plant Cell is in its 19th year of publication. Within three years of its initial publication, it ranked first in impact among primary research journals in the plant sciences, a standard of ...