Our body is constantly surveilled by innate immune cells, ready to initiate host defense or repair responses. Upon recognizing molecular patterns associated with pathogens or damage, innate immune ...

Agonists for innate immune system receptors such as TLRs and STING have shown promising anti-cancer efficacy in preclinical studies, but their clinical success has been limited. Reporting in Nature, ...

Along with defending against pathogens, the body's innate immune system helps to protect the stability of our genomes in unexpected ways—ways that have important implications for the development of ...

Unlike transient innate immune activation, trained immunity is characterized by long-lasting but reversible functional reprogramming of monocytes, macrophages, natural killer (NK) cells, and ...

Researchers have shown that innate immune training, also known as trained immunity (TRIM), leads to aggravated bone loss in experimental models of periodontitis and inflammatory arthritis. Clinical ...

Secondary infections caused by bacteria or viruses during hospital care remain a long-standing global challenge, despite advances in modern medicine. In particular, mixed bacterial–viral infections in ...