Sirtuin 1 (SIRT1), the mammalian homolog of SIR2, was originally identified as a NAD-dependent histone deacetylase, the activity of which is closely associated with lifespan under calorie restriction.

While the search for elixir of life has captivated human imagination for millennia, researchers around the world have put in efforts to extend healthy lifespan and reduce the burden of morbid diseases ...

Sirtuins (SIRTs) are proteins that regulate many cellular processes including mitochondrial function and genome integrity. In mammals, SIRT1-SIRT7 have been discovered, among which SIRT1 is the most ...

Sirtuin genes and the proteins they encode were already linked to longevity in yeast. Now, a previously overlooked member of the family has excited researchers who study aging At last, a member of the ...

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive type of leukemia. Despite advances in treatments, patients have an extremely poor prognosis, highlighting the need to explore the genetic ...

The potential protective effect of sirtuin enzymes in age-related diseases, including cardiovascular diseases, remains an area of intense investigation. Now, researchers has determined that sirtuin 1 ...

A handful of genes that control the body's defenses during hard times can also dramatically improve health and prolong life in diverse organisms. Understanding how they work may reveal the keys to ...