In prime time, the reigning champion Philadelphia Eagles will look to maintain their hold on the NFC's No. 1 seed against a high-flying Detroit Lions offense. Week 11 wraps up with a pair of sub-.500 teams looking to get back on track as the Las Vegas Raiders host the Dallas Cowboys on "Monday Night Football."

A pair of star pass-catchers will be on display when Christian McCaffrey and the San Francisco 49ers (6-4) visit Trey McBride and the Arizona Cardinals (3-6) on Sunday, November 16, 2025.

In addition to his 1,249 passing yards and 70.1% completion percentage this season, Lamar Jackson has tallied 15 touchdowns against one interception.