Week 5 was one of the more unpredictable ones we've seen in the early 2025 NFL season. Fortunately for fantasy managers, it didn't bring another avalanche of significant injuries.

Week 6 Fantasy Busts: Sit 'Em picks feature Derrick Henry, Trevor Lawrence, Alvin Kamara originally appeared on The Sporting News. Add The Sporting News as a Preferred Source by clicking here.

A ton of upsets occurred in the NFL in Week 6, as the San Francisco 49ers, Denver Broncos, Tennessee Titans, Carolina Panthers, Tampa Bay Buccaneers, Washington

We are one-third of the way into the 2025 fantasy football regular season, making this a perfect time for managers to hit the waiver wire and make significant roster adjustments.

Kickoff is at 8:15 p.m. ET from MetLife Stadium in East Rutherford, N.J. The latest Giants vs. Eagles odds have Philadelphia as the 7.5-point favorite. The over/under for total points is 40.5, making it the second-lowest of NFL Week 6.

In a loss to Ole Miss, Kentucky punted on both its first-quarter drives before the Rebels quarterback threw an interception on his own 31 and gave the Wildcats a short field and a third first-quarter possession.

The Penn State Nittany Lions and Texas Longhorns are not just in danger of missing the College Football Playoff, but not being included in the discussion at all in the latter part of the college football season.

Cardinals vs. Colts (-5.5), Browns vs. Steelers (-5.5), Chargers vs. Dolphins (+4.5) and Titans vs. Raiders (-4.5) are some other games with a line more than four points to consider for NFL survivor picks. Before finalizing any Week 6 NFL survivor picks, see which team the red-hot SportsLine Projection Model just went all-in on.