Because mtDNA is only passed down along maternal lines and mutates at predictable rates, it has been used to help trace migration routes of early humans. In this activity, students will learn how ...

One study reported 8 live births from 22 women with pathogenic mtDNA variants who underwent mitochondrial donation through pronuclear transfer. None had signs of mitochondrial disease and heteroplasmy ...

Provide each team with a copy of "The Hunt for mtDNA" student handout. Explain to students what mtDNA is, how it differs from nuclear DNA, and how it is inherited (see Activity Answer for more ...

The vast majority of our DNA—the chromosomes in the nucleus of each cell—is just what you’d expect: a mix of genetic material from both mother and father. But mitochondria are an exception. They ...

Children born to women who carry pathogenic variants in mitochondrial DNA (mtDNA) are at risk for a range of clinical syndromes collectively known as mtDNA disease. Mitochondrial donation by ...

Bert Ely, a biologist at the University of South Carolina, explains. Mitochondrial DNA (mtDNA) is passed from a mother to her children. Fathers cannot pass on their mtDNA, only the extra genetic ...

Pathogenic variants in mitochondrial DNA (mtDNA) are a common cause of severe, often fatal, inherited metabolic disease. A reproductive care pathway was implemented to provide women carrying ...

Understanding the relationship between mtDNA and animal growth could provide valuable information for selective breeding in aquaculture. However, the complex interactions between genetics and ...

When a four-year-old boy was brought to the Cincinnati Children’s Hospital Medical Center with fatigue, muscle pain and muscle weakness, doctors suspected there might be something wrong with his ...

Mitochondrial donation through pronuclear transfer resulted in several live births and reduced transmission of pathogenic mitochondrial DNA (mtDNA) variants, researchers reported. The study involved ...