Brandon Aiyuk’s lackluster opening to the season cannot continue with Deebo Samuel and Christian McCaffrey sidelined.

Brandon Aiyuk caught four passes for 43 yards in the San Francisco 49ers' Week 2 loss to the Minnesota Vikings. While it may ...

Since Brocky Purdy became the starting QB in 2022, Aiyuk has played in six games without Deebo Samuel. In these contests, ...

Everything you need to know about the Rams' home game against the NFC West rival San Francisco 49ers, including start time, ...

It appears the San Francisco 49ers are quickly seeing some of the adversity generated when a wide receiver misses all of ...

Jimmy Garoppolo knows what it feels like as a San Francisco 49er to come to L.A., but now the quarterback is on the other ...

Matchups are a driving force behind weekly lineup decisions in fantasy football. Here are the most and least favorable ...

Just as the San Francisco 49ers won’t miss seeing Aaron Donald lining up for the Los Angeles Rams on Sunday, Sean McVay won’t ...

As the San Francisco 49ers set their sights on another deep playoff run this season, wide receiver Deebo Samuel is making one ...

Samuel (calf) won't practice Thursday, Jennifer Lee Chan of NBC Sports Bay Area reports.

Injuries already are accruing across the league, knocking out several star players and forcing teams to turn to backups and ...

Defensive coordinator Nick Sorensen and run game coordinator and offensive line coach Chris Foerster reviewed the 49ers ...