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Antithrombin study proposes new mechanism of action for the plasma protein's functional roleAntithrombin ligands and candidate receptor genes were co-expressed in HEK293T cells, and the candidate receptors bound to the ligand were identified by immunoprecipitation. The research is ...
They exert their effect by binding to antithrombin, which inhibits both activated factor X and thrombin via a specific pentasaccharide sequence. This binding results in a conformational change in ...
The study was approved by the Ethics Committee (Krakow District Medical Chamber, Poland; 26/KBL/OIL/2011), and all participants gave written informed consent in compliance with the Declaration of ...
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