For decades, the biology of the intestinal stem cells was considered analogous to that of well-studied hematopoietic stem ...

imageimageThis study reveals the necessity of biallelic functional Kif11 for bipolar spindle assembly in acentrosomal oocytes and a spatially differential requirement for homologous chromosome ...

imageimageThe basis and significance of SUMO1 vs SUMO2/3 conjugation preference remains incompletely understood. Here, deacetylation of SAE2, the SUMO-activating E1 enzyme, during mitosis is found to ...

The primary cilium plays a crucial role in regulating whole-body energy metabolism, as reflected in Bardet-Biedl syndrome (BBS), where ciliary dysfunction leads to obesity due to hyperphagia and white ...

imageimageADP-ribosylation is thought to occur on specific sites to affect specific characteristics of target proteins. Here, it is found to play a more promiscuous role, with PARP7 labelling proteins ...

Pathogenic genetic variants in the NuRD component CHD3 cause Snijders Blok–Campeau Syndrome, a neurodevelopmental disorder manifesting with intellectual disability and craniofacial anomalies. To ...

Defense-associated reverse transcriptase (DRT) systems are implicated in prokaryotic resistance to viral infections, yet the molecular mechanisms underlying their functionality remain largely unknown.