Many or most duplicon SNPs may be nothing more than paralogous sequence variants (PSVs) 3,7,8. Alternatively, gene conversion in duplicons may generate allelic diversity and SNP content 11 , 12 .

To discover SNPs, several copies of each locus must be sampled from a population and compared for sequence differences. Two methods have been described. The first, locus-specific polymerase chain ...

Since most SNPs are relatively rare, many genes between 2 individuals are identical, and therefore, one must genotype (determine the sequence of a variant DNA region) dozens of individuals before ...

Single nucleotide polymorphisms--variants in DNA sequences better known as SNPs and pronounced snips--provide a shortcut to comparing genes and genomes within and among species. The need to study SNPs ...

More often than not, when a researcher needs to genotype samples for a particular single nucleotide polymorphism (SNP), or to measure the expression of a specific gene, they end up having to design ...

Each person’s DNA is composed of enormous sequences of four building blocks that go by the letters A, T, G, and C. The vast majority of these sequences are the same in all people, but about 0.1 ...

This analysis revealed that the SNPs split pretty evenly into two groups, and these two groups corresponded neatly to their two tags (so, for example, fragments containing SNP 8 and SNP 14 always ...

Two Nature reports used a massively parallel sequencing approach to sequence whole human genomes in studies of Yoruba African and Han Chinese individuals, which may have later implications for ...

The goal is to determine how the 3 billion bits of DNA in the human genome, or genetic structure, are organized into sequence variations, ... or SNPs, and some are thought to be related to disease.