A UPS cargo plane burst into flames and crashed shortly after takeoff in Louisville, Kentucky, killing at least 12 people, including a child, authorities said.

The NTSB confirmed a UPS cargo plane's left engine separated during takeoff before a fatal Louisville airport crash that killed 12 people and injured 11 others Tuesday.

Federal investigators looking into the deadly UPS cargo plane crash in Kentucky will closely examine the aircraft’s maintenance records and data recorder after finding that one of its engines fell off during takeoff.

The first civilian victims of the UPS plane crash in Kentucky have been named as a grandfather and his three-year-old granddaughter. The jet was departing Louisville Muhammad Ali International Airport before one of its wings burst into flames shortly after taking off.

Nine people were killed and 11 injured after a UPS MD-11 freighter crashed and exploded shortly after takeoff from Louisville. The NTSB and FAA are investigating, with early focus on a possible engine separation.

LOS ANGELES (Reuters) -UPS said on Wednesday it would reopen its sprawling air cargo hub in Louisville, Kentucky, after temporarily shuttering it a day earlier due to a deadly plane crash, a move that will begin easing delays in the delivery firm's global network.

Two businesses were directly affected by the UPS plane crash Nov. 4: Kentucky Petroleum Recycling and Grade A Auto Parts.

The Louisville Metro Police Department said multiple agencies are responding to a reported plane crash near the Louisville Airport.