A disastrous fifth inning doomed the Giants in San Francisco's 8-4 loss to the San Diego Padres on Thursday afternoon at Petco Park.

Bob Melvin did not hold back on how frustrating Thursday night was for the Giants in their loss to the Padres.

The San Diego Padres (71-56) and San Francisco Giants (61-66) will meet on Thursday at PETCO Park, with first pitch at 4:10 p.m. ET. The Padres are the home favorite (-139) versus the Giants (+118). The Padres will start Dylan Cease (5-11) against the Giants and Justin Verlander (1-9).

Heliot Ramos, Rafael Devers and Wilmer Flores homered off Nestor Cortes in the first inning and the San Francisco Giants beat San Diego 4-3 to hand the Padres their fourth straight loss.

Video replay controversy costs the Padres in a 4-3 loss to the Giants, as Xander Bogaerts' home run was overturned for fan interference despite the video showing otherwise.

Gavin Sheets hit two of San Diego's four home runs and drove in four runs, and Fernando Tatis Jr. robbed Giant's Rafael Devers of a homer.

The San Diego Padres took the series over the San Francisco Giants on Thursday, winning three of four games despite playing the entire set without star centerfielder Jackson Merrill. The 22-year-old exited Sunday’s game against the Los Angeles Dodgers early with a bone bruise in his left ankle, after initially tweaking it a couple of games prior.

Petco park erupted in boos after a security guard brutally tackled a San Diego Padres kid who ran out on the field.