MIT Neuroscientists Discover a Tiny Brain Receptor That Could Transform Fragile X Treatment
MIT neuroscientists have made a breakthrough in treating fragile X syndrome by leveraging a novel neurotransmitter signaling ...
News Medical1d
New approach shows promise for treating fragile X syndrome
Building on more than two decades of research, a study by MIT neuroscientists at The Picower Institute for Learning and Memory reports a new way to treat pathology and symptoms of fragile X syndrome, ...
Ginger compound has potential to treat inflammatory bowel disease
An international team led by researchers at the University of Toronto has found a compound in ginger, called furanodienone ...
News Medical2d
Ginger's furanodienone compound may offer new treatment for inflammatory bowel disease
An international team led by researchers at the University of Toronto has found a compound in ginger, called furanodienone ...
technologynetworks3d
Ginger Compound Found to Reduce Gut Inflammation in IBD
Researchers found that furanodienone (FDN), a compound in ginger, activates pregnane X receptor (PXR) to reduce gut ...
Nature17d
Expression of Hepatocyte Transporters and Nuclear Receptors in Children With Early and Late-Stage Biliary Atresia
In addition, alternative sinusoidal efflux transporters, organic solute transporter alpha/beta (OSTα/β) and MRP4 were upregulated, and pregnane X receptor (PXR, NR1I2) levels decreased.
Frontiers19d
Role of nuclear receptor PXR in immune cells and inflammatory diseases
Pregnane X receptor (PXR, NR1I2), a prototypical member of the nuclear receptor superfamily, has been implicated in various processes including metabolism, immune response, and inflammation. The ...
gut.bmj19d
Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease
The bile salt, nuclear farnesoid X receptor (FXR), was recently implicated in intestinal antibacterial defence and barrier function. The aim of this study was to investigate the therapeutic potential ...
The Lancet21d
Peroxisome proliferator-activated receptor α as a novel therapeutic target for schizophrenia
dDepartment of Molecular Brain Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan eLaboratory for Molecular Mechanisms of Brain Development, RIKEN Center for ...