Alzheimer's disease is a debilitating condition that slowly robs people of their memory and cognitive abilities, affecting millions of people worldwide. Familial Alzheimer's disease (FAD), a rare ...

Hippocampal neurons with staining for endosomes (turquoise and purple) and lysosomes (yellow). When the PSEN2 gene is absent or carries a familial Alzheimer-related mutation (middle), the lysosomes ...

Evidence from epidemiological studies suggesting a potential protective effect of anti-inflammatory drugs in Alzheimer's disease (AD) have not been supported by therapeutic studies using nonsteroidal ...

Alzheimer’s Disease (AD) is the result of complex interactions between risk factors that cause pleiotropic changes in molecular networks linking a host of biological processes. A variety of genetic ...

Both presenilin-1 or the less-studied presenilin-2 can act as the catalytic subunit of γ-secretase, the enzyme responsible for churning out Aβ peptides. A new study, published November 29 in Nature ...

Alzheimer’s disease (AD) currently affects 5.5 million people in the U.S. over the age of 65, and that number will continue to grow unless a disease-modifying therapy is created. Even though there is ...

This mutation involves the deletion of an adenine and guanine in intron 11 which abolishes the canonical splice acceptor site of exon 12 (Perrone et al., 2018). This leads to exon 12 skipping and a ...

Abstract Genetics of Alzheimer's Disease and Dementia Genetic Diagnosis, Counselling of AD, and Dementia Clinical Implications for New Drug Development References Genetic Diagnosis, Counselling of AD, ...