San Francisco 49ers quarterback and Iowa State alum Brock Purdy is showing promising signs after being injured on Nov. 17.

The 49ers travel to Buffalo to take on the AFC East-leading Buffalo Bills. Check out our best bet for the game ...

Being without Brock Purdy against the Green Bay Packers stung the San Francisco 49ers. It essentially chalked up the game as ...

San Francisco 49ers quarterback Brock Purdy is the latest star to receive a positive "PupTalk" from the characters of Nickelodeon's PAW Patrol.

NFL Network Insider Tom Pelissero reporting San Francisco 49ers quarterback Brock Purdy did light throwing on Monday.

San Francisco 49ers head coach Kyle Shanahan spoke with reporters via a conference call on Monday, providing several injury ...

The 49ers keep losing key players to injuries. The latest one who could miss time is rookie right guard Dominick Puni. He ...

The Buffalo Bills are fresh off of their bye week heading into a Sunday Night Football matchup with the San Francisco 49ers, ...

Next up for Bills, 9-2, are the beleaguered San Francisco 49ers, 5-6, who limp into Highmark Stadium on Sunday night riding a ...

San Francisco has put up a combined 27 points the past two weeks and faces a Bills defense great at generating pressure with ...

San Francisco quarterback Brock Purdy took part in some light throwing on Monday after missing his first career game because ...

Getting blown out at Green Bay following another squandered late lead the previous week against Seattle has quickly turned ...