For decades, the biology of the intestinal stem cells was considered analogous to that of well-studied hematopoietic stem ...

Although asymptomatic malaria was historically perceived as innocuous, emerging evidence revealed an immunosuppressive signature induced by asymptomatic Plasmodium falciparum infections. To examine if ...

Loss of pluripotency is an essential step in post-implantation development that facilitates the emergence of somatic cell identities essential for gastrulation. Before implantation, pluripotent cell ...

imageimageSTING inhibits LINE-1 retrotransposition to maintain genomic stability in an IFN-independent manner. STING interacts with LINE-1 ORF1p, sorting ORF1p to lysosomes for degradation. STING ...

imageimageThe GndRX system in Legionella pneumophila is a predicted toxin-antitoxin module that causes death during DNA stress. GndRX has non-canonical functionality and appears to be the consequence ...

imageimageIn mouse spermatocytes, the X and Y chromosomes undergo rapid non-homologous synapsis and desynapsis during early pachynema. This study reveals that X-Y desynapsis initiated by the atypical ...

RNA interference (RNAi) is widely used in life science research and is critical for diverse biological processes, such as germline development and antiviral defense. In the germline of Caenorhabditis ...