Adenosine deaminase (also known as adenosine aminohydrolase, or ADA[5]) is an enzyme (EC 3.5.4.4) involved in purine metabolism. It is needed for the breakdown of adenosine from food and for the …

The adenosine deaminase enzyme works to get rid of a molecule called deoxyadenosine, which is generated when DNA is broken down. A buildup of deoxyadenosine in cells can lead to early cell death.

Adenosine deaminase (ADA) is defined as an enzyme that converts adenosine (or deoxyadenosine) into inosine (or deoxyinosine) and ammonia, primarily associated with T lymphocytes in humans.

Oct 3, 2006 · Adenosine deaminase (ADA; also referred to as ADA1), the protein encoded by ADA, serves a housekeeping role in the metabolic interconversion of purine nucleosides in all cells.

What is Adenosine Deaminase Deficiency? Adenosine deaminase (ADA) deficiency is an inherited disease characterized by repeated, persistent, and . otentially life-threatening infections. Symptoms …

Jul 23, 2025 · The adenosine deaminase enzyme breaks down deoxyadenosine, which is generated during DNA breakdown. In ADA deficiency, the absence or severe reduction of this enzyme allows …

Aug 25, 2025 · Adenosine deaminase (ADA) is a crucial metabolic enzyme that plays a vital role in purine metabolism and immune system function. This enzyme catalyzes the irreversible deamination …

Adenosine deaminase (ADA) deficiency (MIM #102700) was the first immunodeficiency in which the specific molecular defect was identified. This autosomal recessive genetic disorder typically leads to …

Dec 4, 2025 · Clinical characteristics: Adenosine deaminase (ADA) deficiency is a systemic purine metabolic disorder that primarily affects lymphocyte development, viability, and function.

May 31, 2023 · Deficiency of adenosine deaminase 2 (DADA2) is a monogenic autoinflammatory disease characterized by systemic vasculitis, early-onset stroke, bone marrow failure, and/or …