Megaloblastic Anemia in Physiology: Causes, Pathogenesis and Clinical Features
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Megaloblastic Anemia in Physiology: Causes, Pathogenesis and Clinical Features
Megaloblastic anemia is a disorder of red blood cell maturation caused by defective DNA synthesis, most commonly due to deficiency of vitamin B₁₂ or folic acid. In physiology, impaired thymidine synthesis leads to delayed nuclear maturation with normal cytoplasmic development, resulting in large, immature red cells (megaloblasts) in the ...
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